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KMID : 0376219790160020477
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Chonnam Medical Journal
1979 Volume.16 No. 2 p.477 ~ p.484
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Modification of Prednisolone Hepatotoxicity by prior loading of the reticuloendothelial system with carbon particles.
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Abstract
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The present report was concerned with the role of the liver sinusoidal lining cells in prednisolone hepatotoxicity.
0.5mg/100gm of prednisolone was injected intramuscularly three times in rats following carbon loading of the liver sinus lining cells(the blockade of RES), and the animals were sacrificed 24 hours later.
The morphological alterations of the liver were as follows.
1. In the prednisolone-treated rats, slight to moderate hydropic degeneration and mild fatty degeneration were observed in the hepatocytes without foci of necrosis.
Compared with that of normal rats, PAS-positive materials and RNA granules were decreased, but Acid Phosphatase activity was more or less increased.
2. Prednisolone-treated rats following the carbon loading of the liver sinus lining cells showed severe hepatic injury such as extensive hydropic degeneration, moderate fatty degeneration and some foci of necrosis.
Compared with that of prednisolone-treated rats, PAS-positive materials and RNA granules were moderately decreased and Acid Phosphatase activity was
slightly decreased as well.
From these results, it may be concluded that the blockade of RES influences more profound hepatotoxicity in rats treated with, prednisolone.
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